VICTOR: VIrtual CrossmaTch for mOleculaR typing data

Donor HLA Typing as Genotype List String

Enter Donor's HLA typing data as Genotype List (GL) String of IMGT/HLA alleles in the text box, select the subject's race/ethnic category, and add Candidate's Unacceptable Antigens in the second text area and click on "SUBMIT" to run virtual cross match. Alleles in the GL string should be resolved to specific HLA protein field (2nd field) or fully resolved (full IMGT/HLA allele name). Protein expression specifying characters ("L", "N", "S", "Q") can be used. Characters that specify antigen recognition domain equivalents (“G”, “P”, “g") can also be used. Population-specific HLA frequencies from NMDP are used to assign the most probable UNOS antigen equivalents for donor HLA typing. HLA loci supported are A, B, C, DRB1, DQB1, DRB3/4/5.

Select Broad/Detailed Race

Candidate's Unacceptable Antigens

Probability Threshold

In case of donor's ambiguous HLA typing there is a probability of positive virtual crossmatch for every unacceptable antigen. Users can indicate the probability threshold of their choice in the text area below. Default value is 0.1 and range is 0 through 1. For a value "X" entered by the user all the unacceptable antigens that have probability of positive virtual crossmatch lower than "X" will be excluded by VICTOR.

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Cite VICTOR Tool

Manuscript under preparation

Prototype Tool for Research Use Only